I am originally from Sao Paulo in Brazil, where I graduated from the Federal University of ABC, receiving my double Bachelor of Science and Technology and Biomedical Engineering in 2014. I then continued to earn my MSc from the same university focusing on tissue engineering and in vitro assays for the biological assessment of biomaterials with potential applications in orthopedics. Since 2017, I have been pursuing my Ph.D. at the University of Calgary exploring the mechanisms involved in endogenous repair of articular cartilage, more specifically the role cell cycle activation within mesenchymal stem cells play in the regenerative potential of cartilage in vivo.
I completed my bachelor and masters in Genetic Engineering and Biotechnology from Shahjalal University of Science and Technology, Bangladesh. My PhD research involves exploring the inflammatory signaling of Lubricin/PRG4 fragments. Altered expression and function of PRG4 is associated with changes in inflammatory signaling resulting in the joint diseases (e.g. osteoarthritis). However, the mechanism through which this occurs is unknown and deserves further rigorous study. I’ll characterize PRG4 (e.g. fragmentation pattern) in human synovial fluid samples from arthritis patients and healthy controls. Using a mass spectrometry approach, I’ll determine which proteases are cleaving PRG4 (and where) and examine the effects of these cleavages in vitro and in vivo.
I hold BSc degree in Molecular Biology and MSc in Genetic Engineering and Biotechnology from the University of Belgrade, Serbia. Currently, I am pursuing PhD in Krawetz lab focusing on interaction between lubricin/PRG4 and stem cells in the process of mammalian wound healing. My hypothesis is that the absence of PRG4 is associated with poorer wound healing outcomes, as well as an increased inflammatory response. My goal is to unravel the mode of action of PRG4 in wound healing and exploit it for therapeutic purposes.